Samantha Ruth Prabhu

The story of Mersal unfurls in three different time periods, in which Vijay plays three different characters, a doctor, a magician and a village leader from Madurai. In this action thriller film, a magician and a doctor attempt to solve a healthcare threat that is looming large over the country and in the process expose the corruption in the Indian medical industry.

Karthik returns to India after completing his education in the United States. His mother wants him to get married to her brother's daughter Indu. A dispute had left both families separated. Karthik promises to fulfill his mother's wish. He joins Indu's college to convince her to marry him but mistakenly assumes Bhagyam as his uncle's daughter. Later, Karthik realises that Indu is his cousin but she is already in love with another guy. What happens next forms the crux of the story.