Charlie (David Spade) is unhappily living in Florida with his materialistic wife, Nikki (Natasha Leggero) and her two unpleasant twin sons from her ex-husband, Ted-O (Sean Astin). He is a bank manager in a supermarket and Nikki is cheating on him with Ted-O. Charlie reunites with his old high school buddy (and FBI agent) Max (Adam Sandler) at a high school reunion. Charlie is still driving his old car and is working the same place as in high school. He is in a rut. The next day Nikki wins an all-expense paid trip to Naples, Florida. Turns out that was organized by Max, who takes Charlie to spend a weekend on a yacht Max rented, and Charlie feels young again. Max blows up the yacht to fake their deaths. When Charlie regains consciousness, Max tells him they can now both start new, better lives. He confesses that he is not an FBI agent and is actually a coroner. This allowed him to use two unclaimed cadavers in place of them; Charlie is given the new identity of Dr. Ronald P. Fishman, and Max takes on the new identity of Butch Ryder. Initially appalled, Charlie soon realizes he has no reason to return to his old life after witnessing his lackluster funeral, Nikki reconciling with Ted-O and that the bank has quickly replaced his job role. Max tells Charlie that he found a key in Butch's rectum, which Charlie as a bank manager (he has access to a Federal database that helps him track the location of the bank from which the key originates) determines it belongs to a safe deposit box in Puerto Rico. Traveling to Puerto Rico, they access Butch's safe deposit box, which contains an iPad, money ($1 MM in cash), a letter from Dakota to Butch and the keys to a mansion with a Ferrari. The duo relocates there (Max is looking for something at the house), befriending and later having an orgy with neighbors Dawn (Catherine Bell) and Joan (Jackie Sandler) during which Dawn reveals the original Butch and Ronald bought the mansion in a hurry, implying they were on the run from something. They find out Ronald was married after seeing a picture of his wife on Butch's tablet. At the mansion, Max and Charlie are attacked by a group of assassins led by The Gymnast (Torsten Voges). They escape, and Max admits he's not a coroner, but actually a guidance counselor. He claims he found Butch and Ronald dead, from bullets. Butch is on the FBI's most wanted list. They return to the continental U.S. to find Ronald's widow, Heather (Paula Patton) at her home in Savannah, Georgia. Max and Charlie explain to her that Ronald was murdered (Butch and Ronald were riding motorcycles together. Ronald was a doctor but was now involved in pharmaceutical research) and infer that Butch got Ronald entangled in criminal activity. Heather tells them that Ronald's study was broken into recently. The trio head to a biker bar where Ronald and Butch used to meet up. At the bar, they learn from a biker, Dakota (who is a huge guy), that Butch had stage four cancer. Ronald had developed a "magic bullet" cancer treatment, and they began conducting secret, non-FDA approved clinical trials. When Ronald's financier, Shecky (Matt Walsh), withdrew funding, Butch started robbing banks (Thats how he landed on FBI's most wanted list). Dakota (Stan Ellsworth) reveals that Ronald and Butch had an affair, but right then Dakota is killed by The Gymnast. The trio escape to Max's mother's house where they are stalked by Max's ex, Becca (Kathryn Hahn) and Charlie ends up having sex with Heather. At Shecky's he reveals that his house was also broken into recently. He had to stop financing the project, as all the banks called in the loans all of a sudden, and for no reason. The trio leave, determining the men who tried to kill them and broke into their homes wanted the cancer treatment formula. Charlie says they should forfeit the formula when they find it, which angers Max. While hacking Ronald's computer, Charlie discovers Max was one of Ronald's cancer patients. He also learns that Max has a young son with Becca and realizes Max had been trying to recover the cure to save his own life. Returning to Shecky's, Max thinks he is withholding the cure. Shecky has been shot, but before he dies, reveals the assassins were hired by Trojgaard, the world's largest chemotherapy company, to steal the cure and bury it. The Gymnast, still in the house, takes Max hostage. Meanwhile, at Becca's, Charlie realizes the Jenga app on Butch's tablet actually holds Ronald's cure. Becca tells Charlie that Max had found Butch and Ronald dead in Ronald' clinic and had this idea to impersonate them to get to the cure. He selected Charlie as Charlie was going nowhere in life and was likely to say yes. He attempts to call Max, but The Gymnast destroys Max's phone as he is tortured. Heather then arrives at Shecky's, telling Max that she not only accepted a fortune from Trojgaard to bury the formula when Ronald refused, but also that she was the one who killed Ronald and Butch. Charlie calls Heather, and she claims Max killed Shecky. When they meet, Charlie sees through her lie, and punches her in the face, but she then holds him at gunpoint. Before she can shoot, Max, who had escaped The Gymnast after he accidentally electrocuted himself, knocks her down. Heather then points the gun at them both, but Becca shows up, beats her unconscious, and recovers the tablet. The police arrive, and when they draw their weapons, Becca accidentally throws the tablet into the bay as she puts up her hands. The tablet suffers irreparable damage, but Charlie backed up the formula on a USB. The men are pardoned for their crimes when they offer the cancer treatment as a bargaining chip. Charlie disguises himself as a zombie and gets his revenge at Nikki, Ted-O and the twins. Charlie, Max, Becca, son and mother return to the mansion in Puerto Rico after Max is cured.
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