Jenny/G-Girl is a superhero is New York City. She has powers of flight, armored skin, lightning-fast speed, super strength, super hearing and others, which she uses to fight crime and to bring perpetrators to justice. Matt foils a purse snatcher who tries to steal Jenny Johnson (Uma Thurman)'s purse on the subway. Jenny was sitting next to the door and Matt was trying to ask her out for a cup of coffee, and Jenny was saying no. That's when the subway reached a station, and a snatcher took off with her purse. Matt follows the thief outside the station and into the streets. The thief drops the purse in haste and Matt retrieves it and yells at the thief calling him a coward. The thief now comes at Matt with a bar and Matt has to run and hide inside a dumpster. The thief gets to the dumper and starts heckling Matt, but suddenly the noise stops. Matt emerges from the dumpster to find Jenny there. Matt (Luke Wilson) becomes Jenny's "hero" and starts dating this shy stranger. Vaughn (Rainn Wilson) is Matt's friend from work. Matt was dumped by his crazy girlfriend 6 months ago and was really looking forward to a "normal" relationship. Matt is a project manager at a design firm. During dates, Jenny keeps an ear out for emergencies across the city. In one instance, she excuses herself for a bathroom break, and then flies away to put out a fire at a high rise, before returning to dinner with Matt. After several dates, Jenny displays increasingly neurotic and aggressive behavior, becoming more demanding and ultimately injuring Matt and destroying his bed the first time they have sex. As the relationship develops, Jenny is being observed by a mechanical pigeon that has cameras for eyes and her nights with Matt are seen on camera by Professor Bedlam. Bedlam contacts Matt and wants to know more about Jenny. Matt refuses to share any private details and Bedlam leaves him hanging from the Statue of Liberty and he has to be rescued by G-Girl. As G-Girl is busy rescuing Matt, Bedlam enters her apartment to steal her DNA samples. Soon after, Jenny is hit by a car in the street and is unhurt. Matt cannot believe this. Jenny reveals to him that she is in fact the voluptuous blonde super-heroine, G-Girl, who accidentally received powers such as flight, super-human strength and speed, invulnerability, super breath, heat vision, and super senses after she was exposed to radiation from a crashed meteorite as a teenager. Jenny starts to become more controlling after she reveals her powers, and Matt starts to lose his mind. Hannah (Anna Faris), Matt's co-worker, has a secret crush on him, although she is going out with a handsome but shallow underwear model. As Matt and Hannah's friendship develops further, and after becoming aggravated with Jenny's escalating jealousy, Matt ends the relationship. An enraged Jenny vows to make Matt regret the decision, using her superpowers to publicly embarrass him, throwing his car into space and eventually causing him to lose his job when she strips him naked during an important meeting. Professor Bedlam was formerly Jenny's high school boyfriend, Barry Lambert. They really enjoyed each other's company and while about to become intimate they were interrupted by the crash of the meteor. He saw her obtain superpowers, then watched and became embittered as she ignored him for other guys. something her new charisma made possible. Consequently, he studied to be a super-villain and is now G-Girl's nemesis. Professor Bedlam (Eddie Izzard) contacts Matt in order to enlist his aid in defeating Jenny. Matt refuses and makes plans to leave the city. As he does so he is contacted by Hannah, she has broken up with her cheating boyfriend, and after confessing their feelings to each other, they end up sleeping together. Jenny (as G-Girl) discovers them in bed the next day. Enraged and jealous, she attacks the pair with a great white shark. Angered, Matt contacts Professor Bedlam and agrees to help him defeat her, as long as Bedlam retires from being a super-villain. At his house Matt accidentally sees a room in which he has a shrine showing his secret continuing adoration of Jenny Bedlam instructs Matt to lure Jenny to a meeting where she can be exposed to another meteorite that will draw away her powers, leaving her a mere mortal. Matt agrees and meets Jenny for a candlelit dinner at his apartment, under the pretense of wanting to resume their relationship. Hannah arrives to see Jenny sitting on Matt's lap. The two women fight, and in the struggle Jenny's superhero identity is revealed to Hannah. Bedlam's trap is sprung, and the energy that gave Jenny her powers is drained back into the meteorite, incapacitating Jenny. Professor Bedlam appears but reveals that he has no intention of keeping his promise to retire from villainy and in fact plans to take the powers for himself. While he and Matt fight, Jenny crawls to the charged meteorite attempting to regain her powers; Hannah intervenes just as Jenny grabs the meteorite, which explodes in a burst of power. Both Hannah and Jenny are catapulted off the roof, apparently to their deaths. Jenny appears within seconds, powers restored, threatening even more mayhem. Only the unexpected reappearance of Hannah, who was also exposed to the meteorite's energies, and now possessing the same powers as G-Girl, saves Matt. The second fight between Hannah and Jenny is a full-on super-brawl, destroying part of the neighboring properties. Finally, Matt reasons with them both and they cease fighting. He tells Jenny that Professor Bedlam is her true love. Jenny agrees, she is softened and embraces her former nemesis as the spectators cheer. The next morning, Matt and Hannah meet up with Professor Bedlam (now just "Barry") and Jenny. As cries for help are heard from afar, Jenny and Hannah, who have become partners in crime-fighting, take off to tackle the emergency. Matt and Barry are left holding their girlfriends' purses and clothes and leave to have a beer together.
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